Grey's Anatomy

Fun Facts About the Most Popular Episodes of ‘Grey’s Anatomy’ per Season, Part 1

The only thing better than enjoying a new episode of Grey’s Anatomy? Enjoying a new episode of Grey’s Anatomy along with millions of other people tuning in to the show’s must-see drama. Each of the hours featured in part one of our list below was the highest-rated episode from its season, meaning that during these Thursday nights (and two Sundays), a whole lot of fans got to experience the magic of Shondaland’s longest-running series together.

And even if you’ve watched Grey’s from beginning to end multiple times over the years, you probably don’t know how all the show’s most popular hours came to be. Read on for some fun behind-the-scenes trivia from the first 11 seasons of our fave medical series.


a close up of a man looking concerned

Season 1, Episode 9: “Who’s Zoomin’ Who?”

In the first season finale of Grey’s Anatomy, the docs performed a secret surgery on Richard, George got an STD, and Addison arrived in Seattle in style, putting an end to Meredith and Derek’s happy romance.

Fact No. 1: Despite its shocking cliff-hanger, this episode wasn’t originally meant to be the finale. Shonda Rhimes revealed in 2005 that the crew shot five more episodes to air afterward, but when ABC execs decided they wanted Grey’s and Desperate Housewives to end their seasons on the same night, they moved those other five episodes to season two.

Fact No. 2: To convince the network to allow an STD storyline, the Grey’s Anatomy writers created a “Top 10 Reasons We Can Give George Syphilis” list. Per writers Gabrielle Stanton and Harry Werksman Jr., arguments included “ER hasn’t done it.”

a woman looking sad

Season 2, Episode 16: “It’s the End of the World”

The all-time highest-rated episode of Grey’s aired after the Super Bowl and saw Meredith put her hand on an unexploded bomb inside a patient’s chest.

Fact No. 1: Director Peter Horton told Shondaland that several unforgettable moments were improvised, including paramedic Hannah (Christina Ricci) leaving a bloody handprint on the OR wall.

Fact No. 2: Hours of screaming at the top of her lungs caused Jillian Armenante (Mindy, the patient’s wife) to lose her voice, as she told Shondaland.

a woman sitting looking in shock

Season 3, Episode 17: “Some Kind of Miracle”

After Meredith nearly drowned, she unconsciously reconnected with her dying mom while the doctors tried to save her life.

Fact No. 1: According to Marti Noxon, who co-wrote the episode with Shonda Rhimes, the Grey’s Anatomy team “hotly debated” the moment when a grieving Cristina left the hospital during Meredith’s treatment.

Fact No. 2: The episode was directed by Adam Arkin, who’s no stranger to medical TV dramas; he’s also an actor best known for starring in Chicago Hope.

a woman looking and smiling at a man she's talking to

Season 4, Episode 1: “A Change is Gonna Come”

In this season premiere, the former interns (minus George) began their residencies, Meredith got to know her half-sister Lexie, and Callie struggled to be a good chief resident.

Fact No. 1: Actress Chyler Leigh (Lexie Grey) initially found it intimidating to join the Grey’s Anatomy cast and told The Sydney Morning Herald, “It was like coming into somebody else’s group or circle. … It was a little daunting in the beginning.”

Fact No. 2: Viewers noticed that in the scene when Izzie defibrillated a deer, she put her stethoscope on backward. Oops!

a man carrying a woman into a hospital

Season 5, Episodes 1-2: “Dream a Little Dream of Me”

This two-part season premiere is best remembered for Owen Hunt’s dramatic arrival and Cristina being impaled by an icicle.

Fact No. 1: Owen was only supposed to be a recurring character, but his high energy and chemistry with Cristina caused Grey’s to promote him to a series regular.

Fact No. 2: This episode was nominated for an Emmy Award for Outstanding Makeup.

a woman looking at someone in front of her

Season 6, Episode 1: “Good Mourning”

During this sad hour, viewers learned that Izzie was alive but George had died. The doctors mourned even as Derek and Meredith celebrated their new marriage.

Fact No. 1: Showrunner and writer Krista Vernoff revealed that Ellen Pompeo (Meredith) was very pregnant during this episode’s filming, so the crew had to come up with “creative staging” to hide her body.

Fact No. 2: This was the first episode of Grey’s where Jessica Capshaw (Arizona Robbins) was a series regular and not just a recurring character.

a man sitting down looking somber

Season 7, Episode 1: “With You I’m Born Again”

Following a mass shooting, the doctors tried to heal. Cristina and Owen got engaged, Derek went to jail for reckless driving, and Mer pretended she was totally fine.

Fact No. 1: Like his character Derek, actor/professional race-car driver Patrick Dempsey loves driving fast cars — but thankfully, much more safely than his on-screen persona.

Fact No. 2: Beginning with this episode, Sarah Drew (April) and Jesse Williams (Jackson) became series regulars.

a man sitting down looking somber

Season 8, Episode 10: “Suddenly”

Teddy learned that her husband Henry had died (and that Cristina and Owen hid the news from her), and Meredith and Derek fought for custody of baby Zola.

Fact No. 1: One of the songs in the episode was “Skin” by Zola Jesus, who coincidentally shares the same first name as the baby Mer and Derek were working to adopt.

Fact No. 2: This was the first of several episodes directed by Ron Underwood, who helmed the Hollywood hits Tremors and Mighty Joe Young.

a man holding a baby by a window

Season 9, Episode 1: “Going, Going, Gone”

In the wake of a plane crash, Mark Sloan died from his injuries, Arizona adjusted to being a new amputee, and Cristina moved to Minnesota.

Fact No. 1: Capshaw told TVLine that to make it look like Arizona was missing a leg, the special-effects team digitally removed her real leg from scenes and replaced it with a fake limb.

Fact No. 2: If the song “Portions for Foxes” during Meredith’s scenes with her new interns sounded familiar, it’s because the Rilo Kiley tune was also played during her very first day in season one.

a man and a woman looking at each other

Season 10, Episode 3: “Everybody’s Crying Mercy”

This episode featured Richard recovering from a wild electrocution accident, April finally passing the board exams, and Cristina and Owen taking steps to end their marriage. 

Fact No. 1: Joey Luthman, the actor who played heart-transplant patient Michael, previously played a patient named Evan on Private Practice.

a woman looking at something

Season 11, Episode 1: “I Must Have Lost it on the Wind”

After Cristina left for Europe, Maggie stepped in as the new head of cardio. Derek, meanwhile, gave up his White House gig to be with Meredith and their kids.

Fact No. 1: This was the first episode of Grey’s not to star Sandra Oh, but it did bump Kelly McCreary (Maggie) and Caterina Scorsone (Amelia) up to becoming series regulars.

Fact No. 2: This was the eighth episode of Grey’s directed by Kevin McKidd, who’d go on to helm dozens of other hours of Grey’s.

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